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Chemical Structure : KU-60019
CAS No.: 925701-46-8
Catalog No.: PC-42876Not For Human Use, Lab Use Only.
KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR.
KU-60019 blocks radiation-induced phosphorylation of key ATM targets in human glioma cells, which is 10-fold more effective than KU-55933.
KU-60019 reduces basal S473 AKT phosphorylation and inhibits glioma cell migration and invasion in vitro.
KU-60019 preferentially sensitizes p53-mutant glioma to ionizing radiation in orthotopic xenograft models of GBM.
| M.Wt | 547.6651 | |
| Formula | C30H33N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel- |
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1. Golding SE, et al. Mol Cancer Ther. 2009 Oct;8(10):2894-902.
2. Gamper AM, et al. J Biol Chem. 2012 Apr 6;287(15):12445-54.
3. Biddlestone-Thorpe L, et al. Clin Cancer Res. 2013 Jun 15;19(12):3189-200.
4. Golding SE, et al. Cell Cycle. 2012 Mar 15;11(6):1167-73.
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