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Chemical Structure : KX2-391
CAS No.: 897016-82-9
Catalog No.: PC-42537Not For Human Use, Lab Use Only.
KX2-391(Tirbanibulin, KX 01, KX 2-391) is a highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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KX2-391 (Tirbanibulin, KX 01, KX 2-391) is a highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor.
KX2-391 (Tirbanibulin, KX 01, KX 2-391) inhibits c-Src kinase with GI50s of 1.34 uM and 2.30 μM in NIH3T3/c-Src527F and SYF/c-Src527F cells, respectively.
KX2-391 (Tirbanibulin, KX 01, KX 2-391) causes microtubule disruption in tumor cells.
KX2-391 (Tirbanibulin, KX 01, KX 2-391) is orally active.
| M.Wt | 431.5268 | |
| Formula | C26H29N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyridineacetamide, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)- |
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1. Fallah-Tafti A, et al. Eur J Med Chem. 2011 Oct;46(10):4853-8.
2. Anbalagan M, et al. Mol Cancer Ther. 2012 Sep;11(9):1936-47.
3. Liu T, et al. Clin Cancer Res. 2013 Dec 1;19(23):6532-43.
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