Catalog No.: PC-60641Not For Human Use, Lab Use Only.
L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S.
L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S.
L-006235 exhibits an IC50 of 28 nM at cellular level in human osteoclasts, >1,000-fold selectivity against cathepsin S.
L-006235 reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.
