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Chemical Structure : L-006235
CAS No.: 294623-49-7
Catalog No.: PC-60641Not For Human Use, Lab Use Only.
L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S.
L-006235 exhibits an IC50 of 28 nM at cellular level in human osteoclasts, >1,000-fold selectivity against cathepsin S.
L-006235 reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.
| M.Wt | 466.6 | |
| Formula | C24H30N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
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| Chemical Name/SMILES |
N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide |
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1. Palmer JT, et al. J Med Chem. 2005 Dec 1;48(24):7520-34.
2. Falgueyret JP, et al. J Med Chem. 2005 Dec 1;48(24):7535-43.
3. Svelander L, et al. Eur J Pharmacol. 2009 Jun 24;613(1-3):155-62.
4. Hayami T, et al. Bone. 2012 Jun;50(6):1250-9.
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