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L-732138

Chemical Structure : L-732138

CAS No.: 148451-96-1

L-732138 (L 732138, L732138)

Catalog No.: PC-60341Not For Human Use, Lab Use Only.

L-732138 is a potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L-732138 is a potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.
L-732138 displays >1,000-fold selectvity over the human NK-2 and NK-3 receptors.
L-732138 inhibits substance P-induced inositol phosphate synthesis, abolishes vagally-induced plasma exudation and significantly inhibits exogenous substance enhancement indcued by LPS.

Physicochemical Properties

M.Wt 472.39
Formula C22H18F6N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester

References

1. Cascieri MA, et al. J Biol Chem. 1994 Mar 4;269(9):6587-91.

2. MacLeod AM, et al. J Med Chem. 1994 Apr 29;37(9):1269-74.

3. Pedersen KE, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):319-25.

4. Kuo HP, et al. Br J Pharmacol. 1998 Oct;125(4):711-6.

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