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Chemical Structure : L-771688
Catalog No.: PC-20986Not For Human Use, Lab Use Only.
L-771688 (L-771,688, SNAP 6383) is a potent and selective alpha1A (α1A)-adrenoceptor antagonist with binding Ki of 0.13 nM to α1-adrenoceptors in human prostate tissue.
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L-771688 (L-771,688, SNAP 6383) is a potent and selective alpha1A (α1A)-adrenoceptor antagonist with binding Ki of 0.13 nM to α1-adrenoceptors in human prostate tissue.
L-771688 has Kd values of 71, 43 and 90 pM in cloned human α1A membranes, rat submaxillary gland and rat prostate membranes, respectively.
L-771,688 antagonizesnorepinephrine-induced inositol-phosphate responses in cloned human α1A-adrenoceptors, as well as phenylephrine or A-61603 induced contraction in isolated rat, dog and human prostate, human and monkey bladder neck and rat caudal artery with apparent Kb values of 0.02-0.28 nM.
The contraction of rat aorta induced by norepinephrine was resistant to L-771,688.
| M.Wt | 557.60 | |
| Formula | C28H33F2N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chang RS, et al. Eur J Pharmacol. 2000 Dec 15;409(3):301-12.
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