Chemical Structure : L-771688
CAS No.:
200050-59-5
L-771688
(L-771,688, SNAP 6383)
Catalog No.: PC-20986Not For Human Use, Lab Use Only.
L-771688 (L-771,688, SNAP 6383) is a potent and selective alpha1A (α1A)-adrenoceptor antagonist with binding Ki of 0.13 nM to α1-adrenoceptors in human prostate tissue.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
L-771688 (L-771,688, SNAP 6383) is a potent and selective alpha1A (α1A)-adrenoceptor antagonist with binding Ki of 0.13 nM to α1-adrenoceptors in human prostate tissue.
L-771688 has Kd values of 71, 43 and 90 pM in cloned human α1A membranes, rat submaxillary gland and rat prostate membranes, respectively.
L-771,688 antagonizesnorepinephrine-induced inositol-phosphate responses in cloned human α1A-adrenoceptors, as well as phenylephrine or A-61603 induced contraction in isolated rat, dog and human prostate, human and monkey bladder neck and rat caudal artery with apparent Kb values of 0.02-0.28 nM.
The contraction of rat aorta induced by norepinephrine was resistant to L-771,688.
Physicochemical Properties
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M.Wt
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557.60
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Formula
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C28H33F2N5O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=C(COC)NC(N(C(NCCCN2CCC(C3=NC=CC=C3)CC2)=O)[C@H]1C4=CC=C(F)C(F)=C4)=O)OC
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References
1. Chang RS, et al. Eur J Pharmacol. 2000 Dec 15;409(3):301-12.
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