Chemical Structure : LCB 03-0110 dihydrochloride
CAS No.:
1962928-28-4
LCB 03-0110 dihydrochloride
(LCB03-0110)
Catalog No.: PC-63520Not For Human Use, Lab Use Only.
LCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family, as well as Btk and Syk.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family, as well as Btk and Syk; potently inhibits the activated tyrosine kinase activity of DDR2 (IC50=6 nM), and nonactivated form of DDR2 (IC50=145 nM); suppresses collagen-induced autophosphorylation of DDR1 and DDR2 with IC50 of 164 and 171 nM in cell-based assays; inhibits all eight Src family kinases with IC50 of 2-20 nM; suppresses the proliferation and migration of primary dermal fibroblasts induced by TGF β1 and type I collagen (IC50=194 nM), inhibits cell migration and nitric oxide, iNOS, COX2, and TNF-α synthesis in LPS-activated J774A.1 macrophage cells; suppresses hypertrophic scar formation in wound healing models.
Physicochemical Properties
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M.Wt
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490.443
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Formula
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C24H25Cl2N3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
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References
1. Sun X, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9.
2. Jung SH, et al. Br J Dermatol. 2013 Jan;168(1):112-9.
3. Kim BH, et al. Exp Dermatol. 2015 Jul;24(7):503-9.
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