Chemical Structure : LCZ-696
CAS No.:
936623-90-4
LCZ-696
(Sacubitril/Valsartan, LCZ696, LCZ 696)
Catalog No.: PC-45432Not For Human Use, Lab Use Only.
Sacubitril/Valsartan (LCZ696) is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).
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| 25 mg | $198 | In stock | |
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Sacubitril/Valsartan (LCZ696) is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).
Sacubitril/Valsartan (LCZ696) causes dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats.
Sacubitril/Valsartan (LCZ696) provides sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats; orally active.
Physicochemical Properties
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M.Wt
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957.99
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Formula
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C48H60N6Na3O10.5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)
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References
1. Gu J, et al. J Clin Pharmacol. 2010 Apr;50(4):401-14.
2. von Lueder TG, et al. Circ Heart Fail. 2015 Jan;8(1):71-8.
3. McMurray J, et al. Eur Heart J. 2015 Feb 14;36(7):434-9.
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