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Chemical Structure : LFM-A13
CAS No.: 244240-24-2
Catalog No.: PC-45399Not For Human Use, Lab Use Only.
LFM-A13 is a highly specific inhibitor of BTK with Ki of 1.4 uM, IC50 of 17.2 uM, shows no activity against EGFR, IRK, JAK1, JAK3, or HCK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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LFM-A13 is a highly specific inhibitor of BTK with Ki of 1.4 uM, IC50 of 17.2 uM, shows no activity against EGFR, IRK, JAK1, JAK3, or HCK.
LFM-A13 enhances the sensitivity to ceramide- or vincristine-induced apoptosis in BTK+ B-lineage leukemic cells; prolongs the median survival time of VPL-treated mice.
LFM-A13 also inhibits Plk3 with IC50 of 61 uM, prevented bipolar mitotic spindle assembly in human breast cancer cells and glioblastoma cells, delays tumor progression in MMTV/neu transgenic mouse model of HER2 positive breast cancer.
| M.Wt | 360.0014 | |
| Formula | C11H8Br2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
2-Butenamide, 2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-,(2Z)- |
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1. Mahajan S, et al. J Biol Chem. 1999 Apr 2;274(14):9587-99.
2. Uckun FM, et al. Bioorg Med Chem. 2007 Jan 15;15(2):800-14.
3. Uckun FM, et al. Clin Cancer Res. 2002 May;8(5):1224-33.
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