Chemical Structure : LSN3441732
CAS No.:
2963629-69-6
LSN3441732
(LSN-3441732)
Catalog No.: PC-24908Not For Human Use, Lab Use Only.
LSN3441732 is a potent, dimeric apolipoprotein(a) (apo(a)) binder and inhibitor of Lipoprotein(a) (Lp(a)) formation, disrupts the formation of Lp(a) with IC50 of 0.18 nM in in vitro Lp(a) assembly assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LSN3441732 is a potent, dimeric apolipoprotein(a) (apo(a)) binder and inhibitor of Lipoprotein(a) (Lp(a)) formation, disrupts the formation of Lp(a) with IC50 of 0.18 nM in in vitro Lp(a) assembly assays.
3H-LSN3441732 binds to full-length apo(a) with Kd of 0.05 nM, with Bmax = 4.9 fmol ng−1 apo(a).
3H-LSN3441732 has high affinity for single KIV7 (Kd = 2.8 nM) and KIV8 (Kd = 2.0 nM).
LSN3441732 shows improvements in potency and efficacy both in vitro and in vivo compared with the monovalent inhibitor.
Physicochemical Properties
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M.Wt
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567.51
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Formula
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C27H36Cl2N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,2'S)-3,3'-((carbonylbis(azanediyl))bis(3,1-phenylene))bis(2-((R)-pyrrolidin-3-yl)propanoic acid) dihydrochloride
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References
1. Nuria Diaz, et al. Nature. 2024 May;629(8013):945-950.
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