Chemical Structure : LSN3441732
CAS No.:
2963629-69-6
LSN3441732
(LSN-3441732)
Catalog No.: PC-24908Not For Human Use, Lab Use Only.
LSN3441732 is a potent, dimeric apolipoprotein(a) (apo(a)) binder and inhibitor of Lipoprotein(a) (Lp(a)) formation, disrupts the formation of Lp(a) with IC50 of 0.18 nM in in vitro Lp(a) assembly assays.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LSN3441732 is a potent, dimeric apolipoprotein(a) (apo(a)) binder and inhibitor of Lipoprotein(a) (Lp(a)) formation, disrupts the formation of Lp(a) with IC50 of 0.18 nM in in vitro Lp(a) assembly assays.
3H-LSN3441732 binds to full-length apo(a) with Kd of 0.05 nM, with Bmax = 4.9 fmol ng−1 apo(a).
3H-LSN3441732 has high affinity for single KIV7 (Kd = 2.8 nM) and KIV8 (Kd = 2.0 nM).
LSN3441732 shows improvements in potency and efficacy both in vitro and in vivo compared with the monovalent inhibitor.
Physicochemical Properties
|
M.Wt
|
567.51
|
|
Formula
|
C27H36Cl2N4O5
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(2S,2'S)-3,3'-((carbonylbis(azanediyl))bis(3,1-phenylene))bis(2-((R)-pyrrolidin-3-yl)propanoic acid) dihydrochloride
|
References
1. Nuria Diaz, et al. Nature. 2024 May;629(8013):945-950.
Contact Us
sales@probechem.com
