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Chemical Structure : LW106
Catalog No.: PC-22837Not For Human Use, Lab Use Only.
LW106 is a selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor with IC50 of 1.57 uM in IFN‐γ‐stimulated HeLa cells.
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LW106 is a selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor with IC50 of 1.57 uM in IFN‐γ‐stimulated HeLa cells.
LW106 inhibited tumour outgrowth via blocking activity of IDO1 expressed by the host‐derived cells but not the inoculated tumour cells.
LW106 dose‐dependently inhibited outgrowth of IDO1‐nonexpressing tumour cells inoculated in C57BL6 mice but not athymic nude mice or Ido1 −/− mice.
LW106 treatment enhances the infiltration and accumulation of T cells in xenografted tumours.
LW106 treatment results in impaired proliferation and survival of Lewis tumour cells in tandem with reduced recruitment of tumour‐associated stromal cells and accumulation of extracellular matrix.
LW106 treatment inhibits cancer stem cell enrichment in Lewis tumours.
| M.Wt | 245.24 | |
| Formula | C11H11N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rong Fu, et al. Br J Pharmacol. 2018 Jul;175(14):3034-3049.
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