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Chemical Structure : LY-3000328
CAS No.: 1373215-15-6
Catalog No.: PC-62811Not For Human Use, Lab Use Only.
LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $448 | In stock | |
| 50 mg | $748 | In stock | |
| 100 mg | Get quote |
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LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM.
LY-3000328 dispalys >500-fold selectivity over cathepsin L, cathepsint K, cathepsin B, and cathepsin V.
LY-3000328 shows efficacy in a CaCl2-induced AAA (Abdominal Aortic Aneurysm) in vivo model.
| M.Wt | 484.528 | |
| Formula | C25H29FN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate |
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1. Jadhav PK, et al. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42.
2. Payne CD, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1334-42.
3. Steimle A, et al. J Autoimmun. 2016 Dec;75:82-95.
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