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LY-3000328

Chemical Structure : LY-3000328

CAS No.: 1373215-15-6

LY-3000328 (LY3000328, LY 3000328, Z-FL-COCHO)

Catalog No.: PC-62811Not For Human Use, Lab Use Only.

LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM.

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10 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM.
LY-3000328 dispalys >500-fold selectivity over cathepsin L, cathepsint K, cathepsin B, and cathepsin V.
LY-3000328 shows efficacy in a CaCl2-induced AAA (Abdominal Aortic Aneurysm) in vivo model.

Physicochemical Properties

M.Wt 484.528
Formula C25H29FN4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate

References

1. Jadhav PK, et al. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42.

2. Payne CD, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1334-42.

3. Steimle A, et al. J Autoimmun. 2016 Dec;75:82-95.

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