Catalog No.: PC-49006Not For Human Use, Lab Use Only.
LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites.
LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites.
LY344864 inhibited forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors with EC50 of 3 nM.
Oral and intravenous LY344864 administration potently inhibited dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats.
LY 344864 decreased the number of capsaicin-induced c-fos-like immunoreactive cells within trigeminal nucleus caudalis (ID50=0.6 mg/kg).
