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Chemical Structure : Laropiprant
CAS No.: 571170-77-9
Catalog No.: PC-45826Not For Human Use, Lab Use Only.
Laropiprant (MK-0524) is a potent and selective prostaglandin D2 (PGD2) receptor (DP1) antagonist with Ki of 0.57 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Laropiprant (MK-0524) is a potent and selective prostaglandin D2 (PGD2) receptor (DP1) antagonist with Ki of 0.57 nM.
Laropiprant shows weaker affinity for TP (Ki=2.95 nM), no significant activity on EP1, EP2, EP3, EP4, FP, and IP.
Laropiprant inhibits the accumulation of cAMP in washed platelets and in plateletrich plasma challenged with PGD with IC50 of 0.09 nM and 4 nM, respectively.
Laropiprant displays an excellent rat pharmacokinetic profile and efficacious in a sheep model of allergic rhinitis.
| M.Wt | 435.8963 | |
| Formula | C21H19ClFNO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)- |
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1. Sturino CF, et al. J Med Chem. 2007 Feb 22;50(4):794-806.
2. Cheng K, et al. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7.
3. Philip G, et al. J Allergy Clin Immunol. 2009 Nov;124(5):942-8.e1-9.
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