Catalog No.: PC-35738Not For Human Use, Lab Use Only.
Lck inhibitor C8863 (C8863, RK-24466, KIN 001-51) is a potent, selective Lck inhibitor, inhibits Lck (64-509) and LckCD isoforms with IC50 of <1 nM and < 2 nM.
Lck inhibitor C8863 (C8863, RK-24466, KIN 001-51) is a potent, selective Lck inhibitor, inhibits Lck (64-509) and LckCD isoforms with IC50 of <1 nM and < 2 nM.
C8863 displays high selectivity for Lck over a range of receptor, non-receptor tyrosine kinases and seronine/threonine kinases.
C8863 significantly inhibits both VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and ERK pathways, and significantly decreases the expression of PCNA, cyclin D1 and pRb.
C8863 interferes with hESC-derived ECs with IC50 of 2.02 uM.
