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Chemical Structure : Lck inhibitor C8863
CAS No.: 213743-31-8
Catalog No.: PC-35738Not For Human Use, Lab Use Only.
Lck inhibitor C8863 (C8863, RK-24466, KIN 001-51) is a potent, selective Lck inhibitor, inhibits Lck (64-509) and LckCD isoforms with IC50 of <1 nM and < 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
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| 100 mg | Get quote |
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Lck inhibitor C8863 (C8863, RK-24466, KIN 001-51) is a potent, selective Lck inhibitor, inhibits Lck (64-509) and LckCD isoforms with IC50 of <1 nM and < 2 nM.
C8863 displays high selectivity for Lck over a range of receptor, non-receptor tyrosine kinases and seronine/threonine kinases.
C8863 significantly inhibits both VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and ERK pathways, and significantly decreases the expression of PCNA, cyclin D1 and pRb.
C8863 interferes with hESC-derived ECs with IC50 of 2.02 uM.
| M.Wt | 370.456 | |
| Formula | C23H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
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1. Otten C, et al. EMBO Mol Med. 2018 Oct;10(10). pii: e9155.
2. Seo HH, et al. Eur J Pharmacol. 2017 Mar 5;798:35-42.
3. Vazão H, et al. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3022-E3031.
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