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Chemical Structure : Leukadherin-1
CAS No.: 344897-95-6
Catalog No.: PC-38467Not For Human Use, Lab Use Only.
Leukadherin-1 (LA1, GB1275 free base) is a small molecule agonist of leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to ICAM-1 and reduces deadhesion.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 100 mg | $468 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Leukadherin-1 (LA1, GB1275 free base) is a small molecule agonist of leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to ICAM-1 and reduces deadhesion.
Leukadherin-1 (LA1) enhances kidney allograft survival in a mouse model of fully MHC-mismatched orthotopic kidney transplantation.
Leukadherin-1 (LA1) treatment reduced interstitial leukocyte infiltration in the allograft, reduced neointimal hyperplasia and glomerular damage, and prolonged graft survival.
Targeting leukocyte trafficking using LA1, an integrin agonist, is beneficial in preventing lung inflammation and protecting alveolar and vascular structures during hyperoxia.
| M.Wt | 421.485 | |
| Formula | C22H15NO4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid |
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1. Celik E, et al. Biophys J. 2013 Dec 3;105(11):2517-27.
2. Khan SQ, et al. Front Med (Lausanne). 2014 Nov 12;1:45.
3. Jagarapu J, et al. Am J Respir Cell Mol Biol. 2015 Dec;53(6):793-801.
4. Roberts AL, et al. Clin Exp Immunol. 2016 Sep;185(3):361-71.
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