MALT1 inhibitor MI-2 |CAS:1047953-91-2 Probechem Biochemicals

Chemical Structure : MALT1 inhibitor MI-2

CAS No.: 1047953-91-2

MALT1 inhibitor MI-2 (MI 2;MI2)

Catalog No.: PC-42938Not For Human Use, Lab Use Only.

MALT1 inhibitor MI-2 is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84 uM, displays little activity against the related caspase family members caspase-3, -8, and -9.

Packing	Price	Stock
25 mg	$188	In stock
50 mg	$288	In stock
100 mg	$458	In stock
200 mg		Get quote
1 g		Get quote

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Biological Activity

MALT1 inhibitor MI-2 is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84 uM, displays little activity against the related caspase family members caspase-3, -8, and -9.
MALT1 inhibitor MI-2 inhibits cleavage of MALT1 substrates, which is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation.
MALT1 inhibitor MI-2 specifically suppresses ABC-DLBCL in vitro and in vivo.
MALT1 inhibitor MI-2 exhibits GI 50 of 0.2, 0.5, 0.4, and 0.4 uM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells respectively, inhibits nuclear translocation of RelB and p50, and decreases Bcl-xL levels in CLL cells.

Physicochemical Properties

M.Wt	455.7223
Formula	C19H17Cl3N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 46 mg/mL
Chemical Name/SMILES	Acetamide, 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]-

References

1. Fontan L, et al. Cancer Cell. 2012 Dec 11;22(6):812-24.

2. Saba NS, et al. Cancer Res. 2017 Dec 15;77(24):7038-7048.

3. Liu W, et al. Oncotarget. 2016 May 24;7(21):30536-49.

4. Yeh CN, et al. Oncotarget. 2017 Dec 8;8(69):113444-113459.

MALT1 inhibitor MI-2 (MI 2;MI2)

Biological Activity

Physicochemical Properties

References

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