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Chemical Structure : MALT1 paracaspase inhibitor 3
Catalog No.: PC-35426Not For Human Use, Lab Use Only.
MALT1 paracaspase inhibitor 3 is a potent, specific, covalent inhibitor of MALT1 paracaspase with Ki of 10 nM, exhibits 10-and 100-fold improved potency in vitro and in vivo compared with Z-VRPR-fmk.
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MALT1 paracaspase inhibitor 3 is a potent, specific, covalent inhibitor of MALT1 paracaspase with Ki of 10 nM, exhibits 10-and 100-fold improved potency in vitro and in vivo compared with Z-VRPR-fmk.
MALT1 paracaspase inhibitor 3 binds covalently to the catalytic cysteine (C464) of MALT1, induces MALT1 oligomerization.
MALT1 paracaspase inhibitor 3 exhibits potent activity in the Raji-GloSensor MALT1 protease inhibition (IC50=60 nM) and OCI-Ly3 growth inhibition assays (IC50=0.1 uM), selectively inhibits the growth of MALT1 dependent cell lines by decreasing cell proliferation and increasing apoptosis.
MALT1 paracaspase inhibitor 3 downregulated IL10 protein expression in vitro and in vivo, also decreases STAT3 phosphorylation in ABC DLBCL cells; suppresses the growth of ABC DLBCL tumors in vivo.
| M.Wt | 569.476 | |
| Formula | C24H34BrFN6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fontán L, et al. J Clin Invest. 2018 Jul 19. pii: 99436.
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