MBP-11901 | Multikinase inhibitor | Probechem Biochemicals

Chemical Structure : MBP-11901

MBP-11901 (MBP11901)

Catalog No.: PC-47032Not For Human Use, Lab Use Only.

MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM).

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Biological Activity

MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM).
MBP-11901 induces apoptosis and inhibits cell migration and invasion of HepG2 cells.
MBP-11901 binds selectively and tightly to FLT3, MAP4K2, KIT, VEGFR2, and PDGFRβ with Kd values of 295, 1100, 3850, 3550, and 4000 nM, respectively.
MBP-11901 was effective against various human HCC cell lines, leading to the disappearance of most tumors when administered orally in animal models.

Physicochemical Properties

M.Wt	312.391
Formula	C16H16N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-diamino-N-(4-(benzo[d]thiazol-2-yl)phenyl)propanamide

References

1. Park HJ, et al. Cancers (Basel). 2022 Apr 14;14(8):1994.

MBP-11901 (MBP11901)

Biological Activity

Physicochemical Properties

References

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