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Chemical Structure : MBP-11901
Catalog No.: PC-47032Not For Human Use, Lab Use Only.
MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM).
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MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM).
MBP-11901 induces apoptosis and inhibits cell migration and invasion of HepG2 cells.
MBP-11901 binds selectively and tightly to FLT3, MAP4K2, KIT, VEGFR2, and PDGFRβ with Kd values of 295, 1100, 3850, 3550, and 4000 nM, respectively.
MBP-11901 was effective against various human HCC cell lines, leading to the disappearance of most tumors when administered orally in animal models.
| M.Wt | 312.391 | |
| Formula | C16H16N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Park HJ, et al. Cancers (Basel). 2022 Apr 14;14(8):1994.
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