Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MD-265
Catalog No.: PC-23385Not For Human Use, Lab Use Only.
MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53.
MD-265 potently inhibited cell growth and achieved IC50 values of 0.9 nM to 212 nM in acute leukemia cell lines carrying a wild-type p53.
MD-265 is a potent MDM2 degrader and is >200 times more potent than MI-1063 in cell growth inhibition in the RS4;11 cell line.
MD-265 demonstrated no activity in cancer cells harboring mutated p53.
MD-265 achieved complete and persistent tumor regression in the RS4;11 xenograft model without causing any signs of toxicity.
| M.Wt | 921.89 | |
| Formula | C50H51Cl2FN6O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Aguilar A, et al. J Med Chem. 2024 Oct 31. doi: 10.1021/acs.jmedchem.4c01818.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
