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MD102

Chemical Structure : MD102

CAS No.: 2755794-94-4

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MD102 (MD 102)

Catalog No.: PC-21655Not For Human Use, Lab Use Only.

MD102 is a potent transglutaminase 2 (TGase 2; TG2) inhibitor with IC50 of 0.35 uM, shows p53 stabilization effect and anticancer activity at RCC cell lines.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MD102 is a potent transglutaminase 2 (TGase 2; TG2) inhibitor with IC50 of 0.35 uM, shows p53 stabilization effect and anticancer activity at RCC cell lines.
    MD102 exhibits p53 stabilization effect and anticancer effects in the ACHN and Caki-1 RCC cell lines with sulforhodamine B (SRB) GI50 values of 2.15 µM and 1.98 µM, respectively.
    MD102 induced apoptosis and disturbance of the interaction between p53 and TG2 through regulating the p53/AKT/mTOR signaling.
    MD102 (15 mpk, i.p., 50 mpk p.o.) inhibited ACHN xenograft growth in nude mice.

    Physicochemical Properties

    M.Wt 389.99
    Formula C13H4BrCl2FN2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-Bromo-3-fluorophenyl)-5,6-dichloro-1H-benzo[d]imidazole-4,7-dione

    References

    1. Kim GR, et al. Bioorg Chem. 2023 Dec 25;143:107061.

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