Catalog No.: PC-60929Not For Human Use, Lab Use Only.
MET inhibitor Compound 1 is a potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively.
MET inhibitor Compound 1 is a potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively.
MET inhibitor Compound 1 demonstrates potent, broad spectrum activity against MET mutants (V1110I, H1112Y, L1195V, Y1235D, D1228H and M1250T) with IC50 of <1 nM-57 nM, and Y1230 mutants with moderate potency (IC50=25-280 nM).
MET inhibitor Compound 1 displays >50-fold selectivity in a panel of 130 kinases with exception of Fms and TrkA/B/C.
MET inhibitor Compound 1 inhibits MET-dependent tumor cell growth in vivo through decreasing phosphorylaed MET.
