MG-624 |CAS:77257-42-2 Probechem Biochemicals

Chemical Structure : MG-624

MG-624 (MG624;MG 624)

Catalog No.: PC-70038Not For Human Use, Lab Use Only.

A selective antagonist of α7 nAChR that inhibits α-Bgtx binding to α7 with Ki of 106 nM.

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Biological Activity

A selective antagonist of α7 nAChR that inhibits α-Bgtx binding to α7 with Ki of 106 nM; also inhibits ACh elicited currents (I(ACh)) in the oocyte-expressed α7 with IC50 of 109 nM; potently suppresses the proliferation of primary human microvascular endothelial cells of the lung (HMEC-Ls), decreases nicotine-induced early growth response gene 1 (Egr-1) levels in HMEC-Ls, and reduces the levels of Egr-1 on the FGF2 promoter; inhibits angiogenesis of human SCLC tumors in mice.

Physicochemical Properties

M.Wt	451.39
Formula	C22H30NOI
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N,N,N-triethyl-2-(4-styrylphenoxy)ethan-1-aminium iodide(E)-N,N,N-triethyl-2-(4-styrylphenoxy)ethan-1-aminium iodide

References

1. Maggi L, et al. Br J Pharmacol. 1999 Jan;126(1):285-95.

2. Gotti C, et al. Br J Pharmacol. 1998 Jul;124(6):1197-206.

3. Brown KC, et al. Angiogenesis. 2012 Mar;15(1):99-114.

MG-624 (MG624;MG 624)

Biological Activity

Physicochemical Properties

References

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