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Chemical Structure : MG-624
Catalog No.: PC-70038Not For Human Use, Lab Use Only.
A selective antagonist of α7 nAChR that inhibits α-Bgtx binding to α7 with Ki of 106 nM.
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A selective antagonist of α7 nAChR that inhibits α-Bgtx binding to α7 with Ki of 106 nM; also inhibits ACh elicited currents (I(ACh)) in the oocyte-expressed α7 with IC50 of 109 nM; potently suppresses the proliferation of primary human microvascular endothelial cells of the lung (HMEC-Ls), decreases nicotine-induced early growth response gene 1 (Egr-1) levels in HMEC-Ls, and reduces the levels of Egr-1 on the FGF2 promoter; inhibits angiogenesis of human SCLC tumors in mice.
| M.Wt | 451.39 | |
| Formula | C22H30NOI | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maggi L, et al. Br J Pharmacol. 1999 Jan;126(1):285-95.
2. Gotti C, et al. Br J Pharmacol. 1998 Jul;124(6):1197-206.
3. Brown KC, et al. Angiogenesis. 2012 Mar;15(1):99-114.
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