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MGL-3196

Chemical Structure : MGL-3196

CAS No.: 920509-32-6

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MGL-3196 (Resmetirom, VIA-3196, MGL3196)

Catalog No.: PC-42920Not For Human Use, Lab Use Only.

MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM.

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10 mg $78 In stock
25 mg $128 In stock
50 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM.
MGL-3196 shows 28-fold selectivity for THR-β over THR-α in a functional assay.
MGL-3196 exhibits an excellent safety profile and orally bioactive.

Physicochemical Properties

M.Wt 435.221
Formula C17H12Cl2N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-

References

1. Kelly MJ, et al. J Med Chem. 2014 May 22;57(10):3912-23.

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