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Chemical Structure : MGP-39
Catalog No.: PC-22852Not For Human Use, Lab Use Only.
MGP-39 is a first-in-class PROTAC degrader targeting maternal embryonic leucine zipper kinase (MELK), induced potent and rapid degradation of MELK in Burkitt lymphoma cell (Dmax=91.6%), and IC50 of 1.8 uM for RAMOS cell line.
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MGP-39 is a first-in-class PROTAC degrader targeting maternal embryonic leucine zipper kinase (MELK), induced potent and rapid degradation of MELK in Burkitt lymphoma cell (Dmax=91.6%), and IC50 of 1.8 uM for RAMOS cell line.
MGP-39 potently inhibits the phosphorylation of mTOR in accordance with MELK downregulation.
MGP-39 exhibits the lower cytotoxicity against MDA-MB-231 cells compared to MELK inhibitors JNJ-47117096/MELK-8a.
MGP-39 induces cell cycle arrest and apoptosis in BL cells.
| M.Wt | 845.96 | |
| Formula | C44H51N11O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yonghui Sun, et al. RSC Med Chem. 2024 Jun 4;15(7):2351-2356.
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