Catalog No.: PC-22852Not For Human Use, Lab Use Only.
MGP-39 is a first-in-class PROTAC degrader targeting maternal embryonic leucine zipper kinase (MELK), induced potent and rapid degradation of MELK in Burkitt lymphoma cell (Dmax=91.6%), and IC50 of 1.8 uM for RAMOS cell line.
MGP-39 is a first-in-class PROTAC degrader targeting maternal embryonic leucine zipper kinase (MELK), induced potent and rapid degradation of MELK in Burkitt lymphoma cell (Dmax=91.6%), and IC50 of 1.8 uM for RAMOS cell line.
MGP-39 potently inhibits the phosphorylation of mTOR in accordance with MELK downregulation.
MGP-39 exhibits the lower cytotoxicity against MDA-MB-231 cells compared to MELK inhibitors JNJ-47117096/MELK-8a.
MGP-39 induces cell cycle arrest and apoptosis in BL cells.
