Chemical Structure : MI1013
CAS No.:
MI1013
(MI-1013)
Catalog No.: PC-24991Not For Human Use, Lab Use Only.
MI1013 is a potent, selective CRBN-base PROTAC degrader of pregnane X receptor (PXR) designed by connecting SPA70 and pomalidomide with PEG linker, has DC50 of 89 nM and Dmax of 82% in HepaRG cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MI1013 is a potent, selective CRBN-base PROTAC degrader of pregnane X receptor (PXR) designed by connecting SPA70 and pomalidomide with PEG linker, has DC50 of 89 nM and Dmax of 82% in HepaRG cells.
The proteasome inhibitor MG132 prevented the MI1013-induced degradation of PXR, confirming the involvement of the proteasome pathway.
MI1013 does not degrade RXRα and GSPT1.
MI1013 demonstrates a concentration-dependent inhibition of PXR activation by rifampicin.
Physicochemical Properties
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M.Wt
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914.95
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Formula
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C42H46N10O12S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-((1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl)sulfonyl)phenyl)-3-(2-(2-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)propanamide
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References
1. Kamaraj R, et al. J Med Chem. 2025 Jul 12. doi: 10.1021/acs.jmedchem.4c03134.
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