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Chemical Structure : MK-0591
CAS No.: 136668-42-3
Catalog No.: PC-42116Not For Human Use, Lab Use Only.
Quiflapon (MK-0591) is a potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $358 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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Quiflapon (MK-0591) is a potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay.
Quiflapon (MK-0591) has no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs.
Quiflapon (MK-0591) potently inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC50 of 3.1 and 6.1 nM, respectively.
Quiflapon (MK-0591) inhibits excretion of LTE4 in antigen-challenged allergic animal models.
| M.Wt | 587.1713 | |
| Formula | C34H35ClN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)- |
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1. Diamant Z, et al. J Allergy Clin Immunol. 1995 Jan;95(1 Pt 1):42-51.
2. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807.
3. Ménard L, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):808-13.
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