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Chemical Structure : MLT-985
CAS No.: 1832576-25-6
Catalog No.: PC-49482Not For Human Use, Lab Use Only.
MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).
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|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).
MLT-985 showed excellent selectivity against a panel of 23 human proteases (all IC50>10 uM), including cysteine proteases such as Caspase 3 and Cathepsin B, C, K, L and S.
MLT-985 inhibits human PBMC IL-2 release with IC50 of 0.5 uM.
MLT-985 demonstrated activity in cellular ABC-DLBCL models that is consistent with potent and selective inhibition of MALT1, suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells.
MLT-985 demonstrated tumor regression in the CARD11-mutant ABC-DLBCL xenograft model OCILy3.
| M.Wt | 448.27 | |
| Formula | C17H15Cl2N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea |
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1. Jean Quancard, et al. J Med Chem. 2020 Dec 10;63(23):14594-14608.
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