Catalog No.: PC-49482Not For Human Use, Lab Use Only.
MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).
MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).
MLT-985 showed excellent selectivity against a panel of 23 human proteases (all IC50>10 uM), including cysteine proteases such as Caspase 3 and Cathepsin B, C, K, L and S.
MLT-985 inhibits human PBMC IL-2 release with IC50 of 0.5 uM.
MLT-985 demonstrated activity in cellular ABC-DLBCL models that is consistent with potent and selective inhibition of MALT1, suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells.
MLT-985 demonstrated tumor regression in the CARD11-mutant ABC-DLBCL xenograft model OCILy3.
