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MLT-985

Chemical Structure : MLT-985

CAS No.: 1832576-25-6

MLT-985 (MLT985, MV088428)

Catalog No.: PC-49482Not For Human Use, Lab Use Only.

MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).

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    Biological Activity

    MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).
    MLT-985 showed excellent selectivity against a panel of 23 human proteases (all IC50>10 uM), including cysteine proteases such as Caspase 3 and Cathepsin B, C, K, L and S.
    MLT-985 inhibits human PBMC IL-2 release with IC50 of 0.5 uM.
    MLT-985 demonstrated activity in cellular ABC-DLBCL models that is consistent with potent and selective inhibition of MALT1, suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells.
    MLT-985 demonstrated tumor regression in the CARD11-mutant ABC-DLBCL xenograft model OCILy3.

    Physicochemical Properties

    M.Wt 448.27
    Formula C17H15Cl2N9O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea

    References

    1. Jean Quancard, et al. J Med Chem. 2020 Dec 10;63(23):14594-14608.

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