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Chemical Structure : MNK-IN-54
Catalog No.: PC-63075Not For Human Use, Lab Use Only.
MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively.
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MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively.
MNK-IN-54 also inhibits RET, FLT3, VEGFR2 with IC50 <20 nM.
MNK-IN-54 shows GI50 of 51 nM in the growth of K562 cells overexpressing eIF4E.
MNK-IN-54 exhibits antitumor activity in a mouse xenograft model and also reduces the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.
| M.Wt | 584.62 | |
| Formula | C30H32F4N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cherian J, et al. J Med Chem. 2016 Apr 14;59(7):3063-78.
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