Chemical Structure : MNS1-MV
CAS No.:
MNS1-MV
Catalog No.: PC-20635Not For Human Use, Lab Use Only.
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells.
MNS1-MV shows selective toxicity towards adult GBM and pediatric high grade glioma cells with IC50 values of 10.89 μM for MC-BT114 cells, 11.71 μM for MC-PED8 cells and 8.5 μM for SF7761.
MNS1-MV (25 uM) effectively inhibits STAT3 activation and nuclear translocation in both adult GBM and pediatric HGG cells.
MNS1-MV inhibits STAT3 activation via IL-6-mediated STAT3 pathway and not direct JAK2.
MNS1-MV (5-25 uM) induces apoptosis and inhibit migration in adult GBM cells.
Physicochemical Properties
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M.Wt
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584.45
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Formula
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C25H22BrN5O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=S(C1=CC=C(N2N=C(CC3=CC=C(NC(OC(NC)=O)=O)C=C3)C=C2C4=CC=C(Br)C=C4)C=C1)(N)=O
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References
1. Liang Zhang, et al. PLoS One. 2019 Jul 30;14(7):e0220569.
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