MST3 inhibitor LD-1

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Chemical Structure : MST3 inhibitor LD-1

Catalog No.: PC-24897Not For Human Use, Lab Use Only.

MST3 inhibitor LD-1 is a potent, selective inhibitor of MST3 protein kinase (mammalian Ste20-like protein kinase 3, STK24) with IC50 of 122.4 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MST3 inhibitor LD-1 is a potent, selective inhibitor of MST3 protein kinase (mammalian Ste20-like protein kinase 3, STK24) with IC50 of 122.4 nM.
LD-1 displays weak to no activity against homologous kinases YSK1, MST1, and MST2.
shows antiproliferative activities against HepG2, HCT116, H226 cancer cells with GI50 of 0.68-0.83 uM.
LD-1 (0.5-1 uM) induced apoptosis, inhibits the proliferation of HepG2 cells.
LD-1 (40 mg/kg, oral) exhibits antitumor effect on HepG2 xenograft mouse model.

Physicochemical Properties

M.Wt	547.53
Formula	C25H21F4N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)-1,4-dihydroquinoline-3-carboxamide

References

1. Deping Li, et al. Eur J Med Chem. 2025 Jun 28:297:117923.

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