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Chemical Structure : MTK458
CAS No.: 2499962-58-0
Catalog No.: PC-49861Not For Human Use, Lab Use Only.
MTK458 (MTK-458) is a potent, selective and brain penetrant PINK1 activator, MTK-458 promotes the first step in mitophagy.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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MTK458 (MTK-458) is a potent, selective and brain penetrant PINK1 activator, MTK-458 promotes the first step in mitophagy.
MTK458 selectively activates PINK1 by stimulating dimerization and stabilization of the PINK1/TOM complex.
MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy.
MTK458 reduces the PINK1 substrate pS65-Ubiquitin (pUb) in primary neurons and in vivo.
MTK458 drives clearance of pathologic α-synuclein in vitro and in vivo, decreases pS129 α-synuclein aggregates and normalized both brain and corresponding plasma pUb levels in both cellular and animal models of α-synuclein aggregation (PD-like pathology).
| M.Wt | 332.33 | |
| Formula | C17H15F3N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(R)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
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1. Chin RM, et al. bioRxiv. 2023 Feb 15:2023.02.14.528378.
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