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Chemical Structure : MY-5445
CAS No.: 78351-75-4
Catalog No.: PC-61344Not For Human Use, Lab Use Only.
MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.
MY-5445 shows no effect on either adenylate cyclase or guanylate cyclase activity.
MY-5445 inhibits human platelet aggregation by increasing cyclic GMP content.
MY-5445 is a useful probe for elucidating the role of cyclic GMP in platelet aggregation.
| M.Wt | 331.8 | |
| Formula | C20H14ClN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine |
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1. Yamamoto T, et al. J Biol Chem. 1983 Dec 10;258(23):14173-7.
2. Hagiwara M, et al. J Pharmacol Exp Ther. 1984 Feb;228(2):467-71.
3. Souness JE, et al. Br J Pharmacol. 1989 Nov;98(3):725-34.
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