Catalog No.: PC-61344Not For Human Use, Lab Use Only.
MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.
MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.
MY-5445 shows no effect on either adenylate cyclase or guanylate cyclase activity.
MY-5445 inhibits human platelet aggregation by increasing cyclic GMP content.
MY-5445 is a useful probe for elucidating the role of cyclic GMP in platelet aggregation.
Physicochemical Properties
M.Wt
331.8
Formula
C20H14ClN3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
References
1. Yamamoto T, et al. J Biol Chem. 1983 Dec 10;258(23):14173-7.
2. Hagiwara M, et al. J Pharmacol Exp Ther. 1984 Feb;228(2):467-71.
3. Souness JE, et al. Br J Pharmacol. 1989 Nov;98(3):725-34.
