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MY-5445

Chemical Structure : MY-5445

CAS No.: 78351-75-4

MY-5445 (MY5445)

Catalog No.: PC-61344Not For Human Use, Lab Use Only.

A specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively; shows no effect on either adenylate cyclase or guanylate cyclase activity; inhibits human platelet aggregation by increasing cyclic GMP content; a useful probe for elucidating the role of cyclic GMP in platelet aggregation.

Physicochemical Properties

M.Wt 331.8
Formula C20H14ClN3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine

References

1. Yamamoto T, et al. J Biol Chem. 1983 Dec 10;258(23):14173-7.

2. Hagiwara M, et al. J Pharmacol Exp Ther. 1984 Feb;228(2):467-71.

3. Souness JE, et al. Br J Pharmacol. 1989 Nov;98(3):725-34.

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