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Chemical Structure : Mirk-IN-1
Catalog No.: PC-43249Not For Human Use, Lab Use Only.
Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM.
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Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM; weakly inhibits DYRK1A, ABL, FLT3, and MARK1 with 88%, 64%, 56% and 73% at 10 uM, shows no activity against the other kinases in the Caliper assay panel; blocks tumor cells from undergoing reversible arrest in a quiescent G(0) state and enables some cells to exit quiescence, elevates ROS levels and DNA damage detected by increased phosphorylation of the histone protein H2AX and by S-phase checkpoints; sensitizes cells to gemcitabine and cisplatin.
| M.Wt | 498.3182 | |
| Formula | C23H17Cl2N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.
2. Anderson K, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.
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