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Chemical Structure : MsbA inhibitor TBT1
CAS No.: 52535-76-9
Catalog No.: PC-63580Not For Human Use, Lab Use Only.
MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MsbA inhibitor TBT1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA transporter, an ATP-dependent flippase that translocates LPS across the inner membrane.
TBT1 causes mislocalization of LPS to the cell interior, inhibits Δ5 strain with MIC of 0.2 ug/ml.
TBT1 binds adjacent yet separate pockets in the MsbA transmembrane domains.
TBT1 is a LPS transport inhibitor and MsbA ATPase stimulator in strains from the Acinetobacter genus
| M.Wt | 335.802 | |
| Formula | C16H14ClNO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid |
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1. Zhang G, et al. Proc Natl Acad Sci U S A. 2018 May 7. pii: 201804670.
2, Thélot FA, et al. Science. 2021 Oct 29;374(6567):580-585.
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