Chemical Structure : MtbFadD32 inhibitor M1
CAS No.:
924871-27-2
MtbFadD32 inhibitor M1
Catalog No.: PC-23766Not For Human Use, Lab Use Only.
MtbFadD32 inhibitor M1 is a small molecule inhibitor of Mycobacterium tuberculosis fatty acyl-AMP ligase FadD32 and FadD28, shows specific antitubercular activity with IC50 of 4.8 ug/mL, binds and inhibits the FAAL activity of MtbFadD32 and MtbFadD28 enzymes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MtbFadD32 inhibitor M1 is a small molecule inhibitor of Mycobacterium tuberculosis fatty acyl-AMP ligase FadD32 and FadD28, shows specific antitubercular activity with IC50 of 4.8 ug/mL, binds and inhibits the FAAL activity of MtbFadD32 and MtbFadD28 enzymes.
M1 is inactive against E. coli up to 200 μg/mL concentration.
M1 in combination with frontline TB drugs rifampicin (R) and isoniazid (I) exhibited better activity against Mtb than M1 alone.
M1 displays uncompetitive inhibition for MtbFadD32 with respect to lauric acid with Ki of 48.1 uM and partial noncompetitive inhibition for ATP with Ki of 55.3 uM.
M1 (2.5 mg/kg body weight, i.p.) reduces lung-associated mycobacterial burden in chronic model of TB infection.
Physicochemical Properties
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M.Wt
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386.95
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Formula
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C10H4Br2F3NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,4-dibromo-6-[3-(trifluoromethyl)-1,2-oxazol-5-yl]phenol
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References
1. Rani N, et al. J Med Chem. 2025 Jan 9;68(1):270-286.
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