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Chemical Structure : Mz325
Catalog No.: PC-21304Not For Human Use, Lab Use Only.
Mz325 is a potent, selective, dual inhibitor of Sirt2/HDAC6 with IC50 of 320/43 nM, respectively.
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Mz325 is a potent, selective, dual inhibitor of Sirt2/HDAC6 with IC50 of 320/43 nM, respectively.
Mz325 displays no inhibitory acitvities against Sirt1 and Sirt3, shows little activity against HDAC1/2/3 (IC50=2-6 uM).
Mz325 (20 μM) increases α-tubulin acetylation levels in PC-3M-luc prostate cancer cells.
Mz325 can induce dual inhibition of the tubulin deacetylases Sirt2 and HDAC6 on a cellular level.
Mz325 reduces the viability of a panel of solid cancer cell lines of different chemosensitivity and tissue origin, including HGC27 gastric carcinoma cells, W1 ovarian cancer cells, MCF-7 breast cancer cells, and PC-3M-luc prostate cancer cells.
| M.Wt | 771.96 | |
| Formula | C38H45N9O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Laura Sinatra, et al. J Med Chem. 2023 Oct 30. doi: 10.1021/acs.jmedchem.3c01385.
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