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Chemical Structure : NCOA4 PROTAC V3
Catalog No.: PC-22832Not For Human Use, Lab Use Only.
NCOA4 PROTAC V3 is a highly efficient VHL-based nuclear receptor coactivator 4 (NCOA4) PROTAC degrader (DC50=3 nM, HeLa cells) and potent ferroptosis inhibitor.
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NCOA4 PROTAC V3 is a highly efficient VHL-based nuclear receptor coactivator 4 (NCOA4) PROTAC degrader (DC50=3 nM, HeLa cells) and potent ferroptosis inhibitor.
NCOA4 PROTAC V3 induces the degradation of NCOA4 via the UPS system in HeLa cells.
NCOA4 PROTAC V3 exhibits a concentration-and time-dependent capacity to attenuate the intracellular levels of NCOA4 in AML12 cells, with a calculated DC50 of 202 nM.
NCOA4 PROTAC V3 upregulates FTH1 and FTL levels in AML12 cells in a concentration-dependent manner, with no significant changes in the mRNA levels of FTH1 and FTL.
NCOA4 PROTAC V3 inhibits ferritinophagy and thus reduces the intracellular ferrous iron (Fe2+) level, induces elevation of ferritin.
NCOA4 PROTAC V3 inhibits the ferroptosis induced by CCl4 in AML12 cells, and in livers of CCl4-induced mice acute liver injury model. ameliorated liver damage in a CCl4-induced acute liver injury model.
| M.Wt | 1141.44 | |
| Formula | C62H80N10O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ji J, et al. J Med Chem. 2024 Jul 24. doi: 10.1021/acs.jmedchem.4c00403.
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