Catalog No.: PC-61179Not For Human Use, Lab Use Only.
NIBR-0213 is a potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM).
NIBR-0213 is a potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM).
NIBR-0213 displays potent and comparable potency on human and rat S1P1 with IC50 of 2.0 and 2.3 nM in GTPγ35S assays, 3,000-fold selectivity against human S1P5.
NIBR-0213 inhibits FTY720-phosphate-induced S1P1 internalization at 1 uM, induces long-lasting reduction of peripheral blood lymphocyte counts, shows comparable therapeutic efficacy to Fingolimod in experimental autoimmune encephalomyelitis (EAE).
