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Chemical Structure : NS-5806
CAS No.: 426834-69-7
Catalog No.: PC-61462Not For Human Use, Lab Use Only.
NS-5806 (NS5806) is a potent Kv4.3 channel activator that mediates the transient outward K+ current (Ito).
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|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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NS-5806 (NS5806) is a potent Kv4.3 channel activator that mediates the transient outward K+ current (Ito).
NS-5806 increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 with EC50 of 5.3 uM.
NS-5806 also decays Kv4.1 independent of KChIP2, strongly inhibits Kv1.4 at 10 uM, but has no effect on Kv7.1, Kv11.1 and K(ir)2 currents.
NS-5806 increases ventricular Ito with a leftward shift in Ito activation and accelerated restitution at 10 uM.
| M.Wt | 574.07 | |
| Formula | C16H8Br2F6N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea |
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1. Calloe K, et al. Cardiovasc Res. 2009 Mar 1;81(4):686-94.
2. Gonzalez WG, et al. J Biol Chem. 2014 Nov 14;289(46):32201-13.
3. Lundby A, et al. Br J Pharmacol. 2010 Aug;160(8):2028-44.
4. Cheng H, et al. Physiol Rep. 2017 Mar;5(5). pii: e13172.
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