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NS3861

Chemical Structure : NS3861

CAS No.: 216853-60-0

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NS3861 (NS-3861;NS 3861)

Catalog No.: PC-60819Not For Human Use, Lab Use Only.

A potent, subtype-selective α3β4 nAChR partial agonist with Ki of 0.62 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, subtype-selective α3β4 nAChR partial agonist with Ki of 0.62 nM; selectively activates receptors containing β4- but not β2-subunits, shows no efficacy at α4β2 receptors and only marginal efficacy at α4β4 receptors expressed in oocytes; enhances fecal pellet expulsion in a dose-dependent manner in mice that received long-term, but not short-term, morphine treatment.

Physicochemical Properties

M.Wt 400.29
Formula C12H14BrNS.C4H4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate

References

1. Harpsøe K, et al. J Biol Chem. 2013 Jan 25;288(4):2559-70.

2. Gade AR, et al. J Pharmacol Exp Ther. 2016 Jun;357(3):520-8.

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