Catalog No.: PC-43388Not For Human Use, Lab Use Only.
NVP-TAE226 (TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM, also potently inhibits Pyk2 (IC50=5 nM), 10- to 100-fold less potent against IR, IGF-IR, ALK, and c-Met kinases.
NVP-TAE226 (TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM, also potently inhibits Pyk2 (IC50=5 nM), 10- to 100-fold less potent against IR, IGF-IR, ALK, and c-Met kinases.
TAE226 suppresses the growth and invasion of glioma cells, inhibits extracellular matrix-induced autophosphorylation of FAK Tyr397.
TAE226 also inhibits IGF-I-induced phosphorylation of IGF-IR and activity of its downstream target genes such as MAPK and Akt.
TAE226 significantly increases the survival rate of animals in glioma xenograft model.
