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Chemical Structure : ODM-208
CAS No.: 2231294-96-3
Catalog No.: PC-49349Not For Human Use, Lab Use Only.
ODM-208 (Opevesostat) is a potent, selective, orally bioavailable CYP11A1 inhibitor, inhibits the biosynthesis of pregnenolone with IC50 of 15 nM in NCI-H295R cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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ODM-208 (Opevesostat) is a potent, selective, orally bioavailable CYP11A1 inhibitor, inhibits the biosynthesis of pregnenolone with IC50 of 15 nM in NCI-H295R cells.
ODM-208 is CYP11A1-selective, shows >1,000 selectivity over metabolising CYP enzymes (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4).
ODM-208 is superior in steroid hormone biosynthesis inhibition compared to the non-selective CYP inhibitors ketoconazole and etomidate.
ODM-208 displays pregnenolone production inhibition with IC50 of 108 nM and 2,167 nM with NADPH and without NADPH, respectively.
ODM-208 displays rapid, complete, durable, and reversible inhibition of the steroid hormone biosynthesis in an adrenocortical carcinoma cell model in vitro, in adult non-castrated male mice and dogs, and in patients with CRPC.
ODM-208 (2 mg/kg/day, oral) treatment causes a significant and dose-dependent decrease in the plasma cortisol and testosterone concentrations in adult non-castrated Beagle dogs.
| M.Wt | 418.508 | |
| Formula | C21H26N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)piperidin-4-yl)methoxy)-4H-pyran-4-one |
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1. Mari Karimaa, et al. Mol Cancer Ther. 2022 Sep 21;MCT-22-0115.
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