Catalog No.: PC-72443Not For Human Use, Lab Use Only.
ONC212 (ONC-212) is a potent anti-cancer small molecule, activator of an orphan GPCR GPR132 and Gαq signaling, also is a potent activator of ClpP activator with EC50 of 131 nM.
ONC212 (ONC-212) is a potent anti-cancer small molecule, activator of an orphan GPCR GPR132 and Gαq signaling, also is a potent activator of ClpP activator with EC50 of 131 nM.
ONC212 possesses highly increased antitumor activity compared to the first-generation compound ONC201.
ONC212 induced apoptogenic effects through the induction of an integrated stress response, and reduced MCL-1 expression.
Oral administration of ONC212 inhibited AML growth in vivo and improved overall survival in xenografted mice.
ONC212 exhibited broad-spectrum efficacy at nanomolar concentrations across solid tumors and hematological malignancies.
ONC212 impairs oxidative phosphorylation (OXPHOS) with decrease in mitochondrial-derived ATP production, mitochondrial protease ClpP was identified as an ONC212-binding target.
