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Chemical Structure : Orlistat
CAS No.: 96829-58-2
Catalog No.: PC-20125Not For Human Use, Lab Use Only.
Orlistat ((–)-Tetrahydrolipstatin, Ro-18-0647) is a small molecule inhibitor of pancreatic and gastric lipase, inhibits DAGLα, DAGLβ, ABHD12, ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH) with IC50 of 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $78 | In stock | |
| 250 mg | $118 | In stock | |
| 500 mg | $188 | In stock | |
| 1 g | Get quote |
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Orlistat ((–)-Tetrahydrolipstatin, Ro-18-0647) is a small molecule inhibitor of pancreatic and gastric lipase, inhibits DAGLα, DAGLβ, ABHD12, ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH) with IC50 of 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively.
Orlistat does not inhibit fatty acid amide hydrolase (FAAH) with IC50 of >100 uM.
Orlistat (1 uM) decreases ionomycin-induced production of the endocannabinoid 2-arachidonoyl glycerol (2-AG) in N18TG2 murine neuroblastoma cells.
also inhibits fatty acid synthase (FASN; apparent Ki =0.1 µM)) and inhibits the proliferation of PC3 prostate cancer cells in a concentration-dependent manner.
Orlistat (10 mg/kg) decreases serum cholesterol levels and total body weight in a mouse model of obesity induced by a high-fat diet.
| M.Wt | 495.75 | |
| Formula | C29H53NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-formyl-L-leucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester |
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1. Bisogno, T.et al. J. Cell Biol. 163(3), 463-468 (2003).
2. Hoover, H.S.et al. Bioorg. Med. Chem. Lett. 18(22), 5838-5841 (2008).
3. Bisogno, T.,et al. Biochim. Biophys. Acta 1761(2), 205-212 (2006).
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