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PA-824

Chemical Structure : PA-824

CAS No.: 187235-37-6

PA-824 (PA824;PA 824;Pretomanid;(S)-PA 824)

Catalog No.: PC-42714Not For Human Use, Lab Use Only.

Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.

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Biological Activity

Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
Pretomanid (PA-824) exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL).
Pretomanid (PA-824) shows potent bactericidal activity against MDR M. tuberculosis and promising oral activity in animal infection models.

Physicochemical Properties

M.Wt 359.2574
Formula C14H12F3N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (6S)-

References

1. Stover CK, et al. Nature. 2000 Jun 22;405(6789):962-6.

2. Tyagi S, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2289-93.

3. Lenaerts AJ, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2294-301.

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