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Chemical Structure : PB118
Catalog No.: PC-21394Not For Human Use, Lab Use Only.
PB118 is a potent, selective HDAC6 inhibitor with IC50 of 5.6 nM, shows >1000 times selectively towards HDAC1, reduces alzheimer's disease neuropathology.
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PB118 is a potent, selective HDAC6 inhibitor with IC50 of 5.6 nM, shows >1000 times selectively towards HDAC1, reduces alzheimer's disease neuropathology.
PB118 displays >100-fold selectivity compared to other histone deacetylases (HDACs).
PB118 significantly impacts the aggregation-prone Aβ42 protein and increased its phagocytosis, a process for clearing cell debris and protein aggregates in microglia BV2 cell.
PB118 significantly increases the acetylated α-tubulin levels in BV2 cell, which is a measure of stable microtubule, by inhibiting the activity of HDAC6.
PB118 reduces the IL-6, IL-12p-70, and KC/GRO (CXCL1) cytokines and chemokines which are responsible for neuroinflammatory changes in Alzheimer's disease (AD).
PB118 significantly reduces p-tau levels and Aβ42 generation on 3D-AD human neural culture model.
| M.Wt | 314.36 | |
| Formula | C18H19FN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mondal P, et al. Adv Sci (Weinh). 2023 Nov 21:e2304545.
2. Ping Bai, et al. Acta Pharm Sin B. 2022 Oct;12(10):3891-3904.
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