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Chemical Structure : PD158780
CAS No.: 171179-06-9
Catalog No.: PC-45479Not For Human Use, Lab Use Only.
PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM.
PD158780 inhibits EGFR autophosphorylation in A431 human epidermoid carcinoma cells (IC50=15 nM).
PD158780 potently inhibits the LPA-stimulated MKK1/2 activation and EGFR phosphorylation in HeLa cells.
PD158780 also inhibits the kinase activity of ACK-1 in vitro (IC50=200 nM), inhibits the growth of v-Ha-Ras-transformed NIH 3T3 cells.
| M.Wt | 330.1826 | |
| Formula | C14H12BrN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrido[3,4-d]pyrimidine-4,6-diamine, N4-(3-bromophenyl)-N6-methyl- |
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1. Rewcastle GW, et al. J Med Chem. 1996 Apr 26;39(9):1823-35.
2. Cunnick JM, et al. J Biol Chem. 1998 Jun 5;273(23):14468-75.
3. Nur-E-Kamal A, et al. Mol Cancer Res. 2005 May;3(5):297-305.
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