Catalog No.: PC-60888Not For Human Use, Lab Use Only.
PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM, also inhibits the checkpoint kinases Wee1 and Myt1.
PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM, also inhibits the checkpoint kinases Wee1 and Myt1.
PD166285 inhibits the formation of microcapillaries on Matrigel-coated plastic at 10 nM.
PD166285 inhibits angiogenesis in mice after oral administration (1-25 mg/kg), significantly prolongs tumor regressions in vivo.
