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Chemical Structure : PD166285
CAS No.: 212391-63-4
Catalog No.: PC-60888Not For Human Use, Lab Use Only.
PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM, also inhibits the checkpoint kinases Wee1 and Myt1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM, also inhibits the checkpoint kinases Wee1 and Myt1.
PD166285 inhibits the formation of microcapillaries on Matrigel-coated plastic at 10 nM.
PD166285 inhibits angiogenesis in mice after oral administration (1-25 mg/kg), significantly prolongs tumor regressions in vivo.
| M.Wt | 585.35 | |
| Formula | C26H27Cl2N5O2.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride |
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1. Dimitroff CJ, et al. Invest New Drugs. 1999;17(2):121-35.
2. Bansal R, et al. J Neurosci Res. 2003 Nov 15;74(4):486-93.
3. Panek RL, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1433-44.
4. Wang Y, et al. Cancer Res. 2001 Nov 15;61(22):8211-7.
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