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Chemical Structure : PD173955
CAS No.: 260415-63-2
Catalog No.: PC-42561Not For Human Use, Lab Use Only.
PD173955 is a potent, selective, ATP-competitive Src family kinases inhibitor with IC50 of 22 nM for Src.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PD173955 is a potent, selective, ATP-competitive Src family kinases inhibitor with IC50 of 22 nM for Src.
PD173955 equally inhibits Yes kinase in vitro, weakly inhibits α-FGFR and PDGFR (IC50s=1.6 uM) and no activity against IR and PKC.
PD173955 inhibits the proliferation of MDA-MB-468 and MCF-7 breast cancer cells with IC50 of 0.5 and 1 uM, respectively。
PD173955 also inhibits Bcr-Abl with IC50 of 1-2 nM, c-kit autophosphorylation (IC50=25 nM).
| M.Wt | 443.3489 | |
| Formula | C21H16Cl2N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]- |
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1. Moasser MM, et al. Cancer Res. 1999 Dec 15;59(24):6145-52.
2. Nagar B, et al. Cancer Res. 2002 Aug 1;62(15):4236-43.
3. Wisniewski D, et al. Cancer Res. 2002 Aug 1;62(15):4244-55.
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