PD173955 is a potent, selective, ATP-competitive Src family kinases inhibitor with IC50 of 22 nM for Src.
PD173955 equally inhibits Yes kinase in vitro, weakly inhibits α-FGFR and PDGFR (IC50s=1.6 uM) and no activity against IR and PKC.
PD173955 inhibits the proliferation of MDA-MB-468 and MCF-7 breast cancer cells with IC50 of 0.5 and 1 uM, respectively。
PD173955 also inhibits Bcr-Abl with IC50 of 1-2 nM, c-kit autophosphorylation (IC50=25 nM).
