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Chemical Structure : PF-04457845
CAS No.: 1020315-31-4
Catalog No.: PC-20049Not For Human Use, Lab Use Only.
PF-04457845 (PF 04457845) is a highly potent, selective and covalent fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 7.2 nM (human FAAH).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | $598 | In stock | |
| 1 g | Get quote |
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PF-04457845 (PF 04457845) is a highly potent, selective and covalent fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 7.2 nM (human FAAH).
PF-04457845 displays no activity against other FP-reactive serine hydrolases at 100 uM, as well as a broad panel of 68 targets including receptors, enzymes, ion channels, and transporters.
PF-04457845 is orally bioavailable, and PF-04457845 (10 mg/kg, p.o.) displays antihyperalgesic activity with long duration of action in the CFA model of inflammatory pain in rats.
PF-04457845 does not elicit effect in motility, catalepsy, and body temperature.
| M.Wt | 455.44 | |
| Formula | C23H20F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide |
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1. Sébastien Dilly, et al. Antioxidants (Basel). 2023 Feb 10;12(2):440.
2. Li Yet al. Proc. Natl. Acad. Sci. USA. 2012;109:12526–12531.
3. Ahn K, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):114-24.
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